The role of dorsolateral prefrontal cortex on placebo effect of regulating social pain: A TMS study

doi:10.3724/SP.J.1041.2023.01063

Abstract

WANG Mei, CHENG Si, LI Yiwei, LI Hong, ZHANG Dandan. (2023). The role of dorsolateral prefrontal cortex on placebo effect of regulating social pain: A TMS study. Acta Psychologica Sinica, 55(7), 1063-1073.

Figures/Tables 3

Table 1 Demographical characteristics of the two groups

Items	Sham group (n = 50)	rDLPFC group (n = 50)	Statistics ^a
Gender (male/female)	22/28	24/26	χ² = 0.16, p = 0.688
Age (year)	19.42 ± 0.18	19.66 ± 0.25	t = -0.78, p = 0.437
BDI	6.46 ± 0.99	7.36 ± 0.92	t = -0.67, p = 0.507
LSAS	51.54 ± 3.11	49.62 ± 3.15	t = 0.43, p = 0.666
IRI	47.10 ± 1.51	50.40 ± 1.54	t = -1.53, p = 0.129

Figure 1. Experimental procedures. A, The procedure of the whole experiment. EEG data were recorded during the Placebo condition and the No-placebo condition. B, Illustration of one trial. C, Illustration of TMS electric fields of the two TMS groups (rDLPFC and sham). The color represents the electric field strength, scaled from 0 (blue) to the individual maximums (red). DLPFC means the dorsolateral prefrontal cortex.

Figure 2. Negative emotion rating and LPP results. (A) The ratings of negative emotion. Error bars represent SE. Small circles represent the data of individual subjects. A 9-point scale was used, with higher scores indicating higher levels of negative emotions. *p < 0.05, **p < 0.01 (B) The bar diagram of LPP amplitudes (time window = 1000 to 6000 ms). (C) The grand-mean LPP waveforms across different conditions. The data were averaged from P3, P4, Pz, CP1, and CP2. (D) LPP topographic maps. The topographic maps are the average value of 1 ~ 6 s in the time window.

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